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Glycodendritic structures: tools to interact with DC-SIGN BJPS
Reina,Jose J.; Rojo,Javier.
The key role of carbohydrates in many biological events has attracted the interest of the scientific community. This fact has demanded the access to new tools necessary to understand this role and the interaction of carbohydrates with their corresponding receptors, lectins. Glycodendrimers and glycodendritic structures in general, have demonstrated to be very efficient and interesting tools to intervene in those processes where carbohydrates participate. In this review, we discuss the different glycodendritic structures that have been used to interfere with DC-SIGN, a very attractive lectin involved in infection processes and in the regulation of the immune response.
Tipo: Info:eu-repo/semantics/article Palavras-chave: DC-SIGN; Ebola; Glycodendrimers; Glycofullerenes; HIV; Mannose.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000700009
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Outbreaks of Ebola virus disease in Africa: the beginnings of a tragic saga J. Venom. Anim. Toxins incl. Trop. Dis.
Chippaux,Jean-Philippe.
The tremendous outbreak of Ebola virus disease occurring in West Africa since the end of 2013 surprises by its remoteness from previous epidemics and dramatic extent. This review aims to describe the 27 manifestations of Ebola virus that arose after its discovery in 1976. It provides an update on research on the ecology of Ebola viruses, modes of contamination and human transmission of the disease that are mainly linked to close contact with an infected animal or a patient suffering from the disease. The recommendations to contain the epidemic and challenges to achieve it are reminded.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ebola; Outbreak; Virus; Hemorrhagic fever; Africa.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200209
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Post-exposure treatment of Ebola virus using passive immunotherapy: proposal for a new strategy J. Venom. Anim. Toxins incl. Trop. Dis.
Chippaux,Jean-Philippe; Boyer,Leslie V; Alagón,Alejandro.
Background Better treatments are urgently needed for the management of Ebola virus epidemics in Equatorial Africa. Methods We conducted a systematic review of the literature on the use of passive immunotherapy for the treatment or prevention of Ebola virus disease. We placed findings from this review into the context of passive immunotherapy currently used for venom-induced disease, and recent improvements in manufacturing of polyvalent antivenom products. Results Passive immunotherapy appears to be one of the most promising specific treatments for Ebola. However, its potential has been incompletely evaluated, considering the overall experience and recent improvement of immunotherapy. Development and use of heterologous serum derivatives could protect...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ebola; Epidemics; Immunotherapy; Prophylaxis; Africa.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100203
Registros recuperados: 3
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